Drug interactions
Nevirapine + Ritonavir
Severity: Moderate
Nevirapine and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine can lower ritonavir and other protease inhibitor concentrations, while ritonavir may raise nevirapine exposure. Both agents can also be associated with immune reconstitution inflammatory syndrome after starting antiretroviral therapy.
What this interaction means in plain words
Nevirapine and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Ritonavir belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4 while ritonavir inhibits it, producing opposing and variable changes in exposure.
What to do
Monitor viral load and drug tolerability, including liver function. Watch for inflammatory symptoms after starting therapy in patients with advanced immunosuppression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Nevirapine with Ritonavir?
MediHelp rates the interaction as moderate. Nevirapine and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine can lower ritonavir and other protease inhibitor concentrations, while ritonavir may raise nevirapine exposure. Both agents can also be associated with immune reconstitution inflammatory syndrome after starting antiretroviral therapy.
How serious is the interaction between Nevirapine and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor viral load and drug tolerability, including liver function. Watch for inflammatory symptoms after starting therapy in patients with advanced immunosuppression.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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