Drug interactions
Nevirapine + Roflumilast
Severity: Moderate
Nevirapine and Roflumilast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces CYP3A4 and CYP1A2, which can lower roflumilast and its active N-oxide metabolite exposure. This may reduce the therapeutic effect in COPD.
What this interaction means in plain words
Nevirapine and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Roflumilast belongs to Respiratory.
Why it happens
Induction of CYP3A4 and CYP1A2 increases roflumilast metabolism.
What to do
Monitor COPD control and consider an alternative if efficacy is lost. Avoid combining with strong inducers where an alternative exists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roflumilast
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Nevirapine with Roflumilast?
MediHelp rates the interaction as moderate. Nevirapine and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine induces CYP3A4 and CYP1A2, which can lower roflumilast and its active N-oxide metabolite exposure. This may reduce the therapeutic effect in COPD.
How serious is the interaction between Nevirapine and Roflumilast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor COPD control and consider an alternative if efficacy is lost. Avoid combining with strong inducers where an alternative exists.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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