Drug interactions
Nevirapine + Simvastatin
Severity: Moderate
Nevirapine and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine can substantially reduce simvastatin exposure, leading to inadequate lipid lowering. The effect is clinically relevant because simvastatin depends heavily on CYP3A4.
What this interaction means in plain words
Nevirapine and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Simvastatin belongs to Cardiovascular.
Why it happens
Nevirapine induces CYP3A4, increasing presystemic and hepatic metabolism of simvastatin.
What to do
Monitor the lipid panel and titrate simvastatin as needed, or switch to a statin not reliant on CYP3A4. Reassess when nevirapine is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Frequently asked questions
Can I take Nevirapine with Simvastatin?
MediHelp rates the interaction as moderate. Nevirapine and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine can substantially reduce simvastatin exposure, leading to inadequate lipid lowering. The effect is clinically relevant because simvastatin depends heavily on CYP3A4.
How serious is the interaction between Nevirapine and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the lipid panel and titrate simvastatin as needed, or switch to a statin not reliant on CYP3A4. Reassess when nevirapine is started or stopped.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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