Drug interactions
Nevirapine + Sufentanil
Severity: Minor
Nevirapine and Sufentanil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may decrease sufentanil exposure, potentially reducing analgesia or anesthetic depth. Sufentanil is a CYP3A4 substrate, so induction is plausible, though clinical data are lacking.
What this interaction means in plain words
Nevirapine and Sufentanil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nevirapine belongs to Anti Virals; Sufentanil belongs to Musculoskeletal.
Why it happens
Nevirapine induces CYP3A4, accelerating sufentanil metabolism.
What to do
Titrate sufentanil to analgesic effect and watch for inadequate pain control; monitor for withdrawal or respiratory effects if nevirapine is stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Nevirapine with Sufentanil?
MediHelp rates the interaction as minor. Nevirapine and Sufentanil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nevirapine may decrease sufentanil exposure, potentially reducing analgesia or anesthetic depth. Sufentanil is a CYP3A4 substrate, so induction is plausible, though clinical data are lacking.
How serious is the interaction between Nevirapine and Sufentanil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sufentanil to analgesic effect and watch for inadequate pain control; monitor for withdrawal or respiratory effects if nevirapine is stopped.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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