Drug interactions
Nevirapine + Tinidazole
Severity: Minor
Nevirapine and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces CYP3A4, and tinidazole is partly cleared by this enzyme. Co-administration would be expected to lower tinidazole exposure, possibly reducing its efficacy. The legacy direction (increase) is inconsistent with induction.
What this interaction means in plain words
Nevirapine and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nevirapine belongs to Anti Virals; Tinidazole belongs to Anti Parasitic.
Why it happens
Nevirapine induction of CYP3A4 may increase tinidazole metabolism; the effect is predicted rather than well documented.
What to do
No empirical dose change is needed; assess clinical response to tinidazole and consider a longer course or alternative if treatment fails.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Frequently asked questions
Can I take Nevirapine with Tinidazole?
MediHelp rates the interaction as minor. Nevirapine and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nevirapine induces CYP3A4, and tinidazole is partly cleared by this enzyme. Co-administration would be expected to lower tinidazole exposure, possibly reducing its efficacy. The legacy direction (increase) is inconsistent with induction.
How serious is the interaction between Nevirapine and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; assess clinical response to tinidazole and consider a longer course or alternative if treatment fails.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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