Drug interactions
Nevirapine + Vinblastine
Severity: Moderate
Nevirapine and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vinblastine is metabolized by CYP3A4, and nevirapine may reduce its exposure and potentially its efficacy. Data are scarce.
What this interaction means in plain words
Nevirapine and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Vinblastine belongs to Oncology.
Why it happens
Nevirapine induces CYP3A4, accelerating vinblastine clearance.
What to do
Monitor treatment response and toxicity, and prefer a non-inducing antiretroviral regimen during chemotherapy where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Vinblastine
Frequently asked questions
Can I take Nevirapine with Vinblastine?
MediHelp rates the interaction as moderate. Nevirapine and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vinblastine is metabolized by CYP3A4, and nevirapine may reduce its exposure and potentially its efficacy. Data are scarce.
How serious is the interaction between Nevirapine and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor treatment response and toxicity, and prefer a non-inducing antiretroviral regimen during chemotherapy where feasible.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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