Drug interactions
Nevirapine + Voxelotor
Severity: Moderate
Nevirapine and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and could modestly raise nevirapine levels, increasing the risk of rash and hepatotoxicity. Nevirapine, as an inducer, may in turn lower voxelotor exposure and reduce its efficacy.
What this interaction means in plain words
Nevirapine and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4, reducing nevirapine clearance, while nevirapine induces CYP3A4 and reduces voxelotor levels.
What to do
Monitor liver enzymes and skin reactions, and assess hemoglobin response to voxelotor. Consider an alternative antiretroviral if toxicity or loss of efficacy occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Nevirapine with Voxelotor?
MediHelp rates the interaction as moderate. Nevirapine and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor inhibits CYP3A4 and could modestly raise nevirapine levels, increasing the risk of rash and hepatotoxicity. Nevirapine, as an inducer, may in turn lower voxelotor exposure and reduce its efficacy.
How serious is the interaction between Nevirapine and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and skin reactions, and assess hemoglobin response to voxelotor. Consider an alternative antiretroviral if toxicity or loss of efficacy occurs.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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