Drug interactions
Nevirapine + Ziprasidone
Severity: Minor
Nevirapine and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone is partly metabolized by CYP3A4, so nevirapine may modestly lower its exposure. Aldehyde oxidase is the main pathway, so the effect is likely small.
What this interaction means in plain words
Nevirapine and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nevirapine belongs to Anti Virals; Ziprasidone belongs to Central Nervous System.
Why it happens
Nevirapine CYP3A4 induction increases the minor oxidative clearance of ziprasidone.
What to do
Monitor psychiatric response and adjust ziprasidone dose to clinical effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Nevirapine with Ziprasidone?
MediHelp rates the interaction as minor. Nevirapine and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ziprasidone is partly metabolized by CYP3A4, so nevirapine may modestly lower its exposure. Aldehyde oxidase is the main pathway, so the effect is likely small.
How serious is the interaction between Nevirapine and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric response and adjust ziprasidone dose to clinical effect.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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