Drug interactions
Nicardipine + Oxycodone
Severity: Minor
Nicardipine and Oxycodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine inhibits CYP3A4 weakly to moderately and may modestly raise oxycodone exposure. Additive hypotension is also possible.
What this interaction means in plain words
Nicardipine and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nicardipine belongs to Cardiovascular; Oxycodone belongs to Musculoskeletal.
Why it happens
Mild CYP3A4 inhibition by nicardipine reduces oxycodone metabolism.
What to do
No routine dose change is required. Monitor for sedation and blood pressure when starting or stopping nicardipine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Nicardipine
Frequently asked questions
Can I take Nicardipine with Oxycodone?
MediHelp rates the interaction as minor. Nicardipine and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine inhibits CYP3A4 weakly to moderately and may modestly raise oxycodone exposure. Additive hypotension is also possible.
How serious is the interaction between Nicardipine and Oxycodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required. Monitor for sedation and blood pressure when starting or stopping nicardipine.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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