Drug interactions
Nicardipine + Palbociclib
Severity: Moderate
Nicardipine and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a moderate CYP3A4 inhibitor, so palbociclib exposure may rise modestly. This may increase neutropenia and other adverse effects.
What this interaction means in plain words
Nicardipine and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Palbociclib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 reduces palbociclib clearance.
What to do
Monitor complete blood counts as per palbociclib labeling and watch for toxicity. Dose reduction of palbociclib is generally reserved for strong inhibitors, but consider it if neutropenia is severe.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Palbociclib
Frequently asked questions
Can I take Nicardipine with Palbociclib?
MediHelp rates the interaction as moderate. Nicardipine and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine is a moderate CYP3A4 inhibitor, so palbociclib exposure may rise modestly. This may increase neutropenia and other adverse effects.
How serious is the interaction between Nicardipine and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts as per palbociclib labeling and watch for toxicity. Dose reduction of palbociclib is generally reserved for strong inhibitors, but consider it if neutropenia is severe.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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