Drug interactions
Nicardipine + Rucaparib
Severity: Minor
Nicardipine and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP3A4 to a modest degree and may raise nicardipine concentrations. This could increase hypotension, flushing, edema and tachycardia.
What this interaction means in plain words
Nicardipine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nicardipine belongs to Cardiovascular; Rucaparib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 metabolism of nicardipine by rucaparib.
What to do
Monitor blood pressure and heart rate and reduce the nicardipine dose if hypotension or other adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Nicardipine with Rucaparib?
MediHelp rates the interaction as minor. Nicardipine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP3A4 to a modest degree and may raise nicardipine concentrations. This could increase hypotension, flushing, edema and tachycardia.
How serious is the interaction between Nicardipine and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and reduce the nicardipine dose if hypotension or other adverse effects occur.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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