Drug interactions
Nicardipine + Ruxolitinib
Severity: Moderate
Nicardipine and Ruxolitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may modestly increase ruxolitinib exposure via CYP3A4 inhibition. This may worsen cytopenias such as thrombocytopenia and anemia.
What this interaction means in plain words
Nicardipine and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Ruxolitinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 reduces ruxolitinib metabolism.
What to do
Monitor blood counts regularly and adjust the ruxolitinib dose according to labeling if cytopenias develop. Strong-inhibitor dose reductions are not routinely required for nicardipine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Nicardipine with Ruxolitinib?
MediHelp rates the interaction as moderate. Nicardipine and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine may modestly increase ruxolitinib exposure via CYP3A4 inhibition. This may worsen cytopenias such as thrombocytopenia and anemia.
How serious is the interaction between Nicardipine and Ruxolitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts regularly and adjust the ruxolitinib dose according to labeling if cytopenias develop. Strong-inhibitor dose reductions are not routinely required for nicardipine.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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