Drug interactions
Nicardipine + Stiripentol
Severity: Moderate
Nicardipine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol has both inhibitory and inducing effects on CYP3A4, so nicardipine exposure may rise or fall unpredictably. This can lead to excess hypotension and edema or to reduced blood pressure control.
What this interaction means in plain words
Nicardipine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol modulates CYP3A4 activity (inhibition and induction), altering the metabolism of nicardipine.
What to do
Monitor blood pressure and heart rate when starting or stopping stiripentol. Adjust the nicardipine dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Stiripentol
Frequently asked questions
Can I take Nicardipine with Stiripentol?
MediHelp rates the interaction as moderate. Nicardipine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol has both inhibitory and inducing effects on CYP3A4, so nicardipine exposure may rise or fall unpredictably. This can lead to excess hypotension and edema or to reduced blood pressure control.
How serious is the interaction between Nicardipine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or stopping stiripentol. Adjust the nicardipine dose according to response.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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