Drug interactions
Nicardipine + Temsirolimus
Severity: Moderate
Nicardipine and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
mTOR inhibitors given with calcium channel blockers have been associated with a higher incidence of angioedema. Nicardipine may also affect temsirolimus exposure through CYP3A4 and P-gp, though this is not well characterized.
What this interaction means in plain words
Nicardipine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Temsirolimus belongs to Oncology.
Why it happens
The mechanism of the angioedema risk is not established; a pharmacokinetic contribution is possible.
What to do
Counsel patients to report lip, tongue or facial swelling promptly. Stop the offending agent if angioedema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Nicardipine with Temsirolimus?
MediHelp rates the interaction as moderate. Nicardipine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. mTOR inhibitors given with calcium channel blockers have been associated with a higher incidence of angioedema. Nicardipine may also affect temsirolimus exposure through CYP3A4 and P-gp, though this is not well characterized.
How serious is the interaction between Nicardipine and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report lip, tongue or facial swelling promptly. Stop the offending agent if angioedema develops.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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