Drug interactions
Nicardipine + Valbenazine
Severity: Minor
Nicardipine and Valbenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine and its active metabolite depend partly on CYP3A4, and nicardipine may modestly raise their levels. The labeled dose reduction applies to strong inhibitors, and nicardipine is weaker, so the effect is likely small. Higher exposure could increase somnolence and QT effects.
What this interaction means in plain words
Nicardipine and Valbenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nicardipine belongs to Cardiovascular; Valbenazine belongs to Central Nervous System.
Why it happens
Nicardipine weakly inhibits CYP3A4, reducing valbenazine metabolism.
What to do
Dose reduction is not routinely required; monitor for sedation and, in at-risk patients, QT changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Nicardipine with Valbenazine?
MediHelp rates the interaction as minor. Nicardipine and Valbenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valbenazine and its active metabolite depend partly on CYP3A4, and nicardipine may modestly raise their levels. The labeled dose reduction applies to strong inhibitors, and nicardipine is weaker, so the effect is likely small. Higher exposure could increase somnolence and QT effects.
How serious is the interaction between Nicardipine and Valbenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Dose reduction is not routinely required; monitor for sedation and, in at-risk patients, QT changes.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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