Drug interactions
Nifedipine + Posaconazole
Severity: Moderate
Nifedipine and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole inhibits CYP3A4 and can substantially increase nifedipine exposure, causing hypotension, reflex tachycardia, edema and flushing. The legacy suggestion that nifedipine lowers posaconazole is of little clinical relevance.
What this interaction means in plain words
Nifedipine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nifedipine belongs to Cardiovascular; Posaconazole belongs to Anti Fungals.
Why it happens
CYP3A4 inhibition by posaconazole reduces nifedipine clearance.
What to do
Monitor blood pressure and consider reducing the nifedipine dose when starting posaconazole. Reassess when the antifungal is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Nifedipine
Frequently asked questions
Can I take Nifedipine with Posaconazole?
MediHelp rates the interaction as moderate. Nifedipine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole inhibits CYP3A4 and can substantially increase nifedipine exposure, causing hypotension, reflex tachycardia, edema and flushing. The legacy suggestion that nifedipine lowers posaconazole is of little clinical relevance.
How serious is the interaction between Nifedipine and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and consider reducing the nifedipine dose when starting posaconazole. Reassess when the antifungal is stopped.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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