Drug interactions
Nifedipine + Tucatinib
Severity: Moderate
Nifedipine and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A and may increase nifedipine exposure. This can cause hypotension, tachycardia and edema.
What this interaction means in plain words
Nifedipine and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nifedipine belongs to Cardiovascular; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A-mediated metabolism of nifedipine.
What to do
Monitor blood pressure and reduce the nifedipine dose if hypotension or edema develops. Consider an alternative antihypertensive if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Nifedipine with Tucatinib?
MediHelp rates the interaction as moderate. Nifedipine and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits CYP3A and may increase nifedipine exposure. This can cause hypotension, tachycardia and edema.
How serious is the interaction between Nifedipine and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and reduce the nifedipine dose if hypotension or edema develops. Consider an alternative antihypertensive if needed.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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