Drug interactions
Nilotinib + Nintedanib
Severity: Moderate
Nilotinib and Nintedanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits P-glycoprotein, which transports nintedanib, so nintedanib exposure may increase. This may worsen gastrointestinal effects and liver enzyme elevations.
What this interaction means in plain words
Nilotinib and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilotinib belongs to Oncology; Nintedanib belongs to Oncology.
Why it happens
Nilotinib inhibition of P-gp efflux increases nintedanib absorption and reduces its clearance.
What to do
Monitor for nintedanib adverse effects and liver tests. Interrupt or reduce the nintedanib dose if intolerance develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
Frequently asked questions
Can I take Nilotinib with Nintedanib?
MediHelp rates the interaction as moderate. Nilotinib and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits P-glycoprotein, which transports nintedanib, so nintedanib exposure may increase. This may worsen gastrointestinal effects and liver enzyme elevations.
How serious is the interaction between Nilotinib and Nintedanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for nintedanib adverse effects and liver tests. Interrupt or reduce the nintedanib dose if intolerance develops.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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