Drug interactions
Nilotinib + Posaconazole
Severity: Major
Nilotinib and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib carries a boxed warning for QT prolongation and is a CYP3A4 substrate, so posaconazole can increase its exposure and the risk of sudden death from torsades de pointes. Posaconazole also prolongs the QT interval, adding to the risk.
What this interaction means in plain words
Nilotinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nilotinib belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
CYP3A4 inhibition raising nilotinib levels plus additive QT prolongation.
What to do
Avoid the combination if possible; if unavoidable, reduce the nilotinib dose per labeling and monitor ECG and electrolytes closely. Consider an echinocandin as an antifungal alternative.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nilotinib and Posaconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Posaconazole?
MediHelp rates the interaction as major. Nilotinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nilotinib carries a boxed warning for QT prolongation and is a CYP3A4 substrate, so posaconazole can increase its exposure and the risk of sudden death from torsades de pointes. Posaconazole also prolongs the QT interval, adding to the risk.
How serious is the interaction between Nilotinib and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if unavoidable, reduce the nilotinib dose per labeling and monitor ECG and electrolytes closely. Consider an echinocandin as an antifungal alternative.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
