Drug interactions
Nilotinib + Sodium zirconium cyclosilicate
Severity: Moderate
Nilotinib and Sodium zirconium cyclosilicate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium zirconium cyclosilicate can raise gastric pH, which may reduce dissolution and absorption of pH-dependent drugs. Nilotinib solubility falls at higher pH, so exposure may drop and efficacy may be reduced.
What this interaction means in plain words
Nilotinib and Sodium zirconium cyclosilicate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilotinib belongs to Oncology; Sodium zirconium cyclosilicate belongs to Miscellaneous.
Why it happens
Increased gastric pH reduces solubility and absorption of nilotinib.
What to do
Give nilotinib at least 2 hours before or after sodium zirconium cyclosilicate, noting nilotinib's fasting requirements. Monitor treatment response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Sodium zirconium cyclosilicate
- Cefditoren + Sodium zirconium cyclosilicate Moderate
- Cefpodoxime + Sodium zirconium cyclosilicate Moderate
- Cefuroxime + Sodium zirconium cyclosilicate Moderate
- Crizotinib + Sodium zirconium cyclosilicate Moderate
- Dasatinib + Sodium zirconium cyclosilicate Moderate
- Erlotinib + Sodium zirconium cyclosilicate Moderate
Frequently asked questions
Can I take Nilotinib with Sodium zirconium cyclosilicate?
MediHelp rates the interaction as moderate. Nilotinib and Sodium zirconium cyclosilicate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium zirconium cyclosilicate can raise gastric pH, which may reduce dissolution and absorption of pH-dependent drugs. Nilotinib solubility falls at higher pH, so exposure may drop and efficacy may be reduced.
How serious is the interaction between Nilotinib and Sodium zirconium cyclosilicate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give nilotinib at least 2 hours before or after sodium zirconium cyclosilicate, noting nilotinib's fasting requirements. Monitor treatment response.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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