Drug interactions
Nimodipine + Rucaparib
Severity: Moderate
Nimodipine and Rucaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a moderate CYP3A4 inhibitor in vitro and may modestly raise nimodipine levels. This could increase hypotension and other vasodilatory effects.
What this interaction means in plain words
Nimodipine and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nimodipine belongs to Cardiovascular; Rucaparib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 by rucaparib reduces nimodipine clearance.
What to do
Monitor blood pressure and heart rate during coadministration. Reduce the nimodipine dose if hypotension or marked vasodilatory adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Nimodipine with Rucaparib?
MediHelp rates the interaction as moderate. Nimodipine and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib is a moderate CYP3A4 inhibitor in vitro and may modestly raise nimodipine levels. This could increase hypotension and other vasodilatory effects.
How serious is the interaction between Nimodipine and Rucaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during coadministration. Reduce the nimodipine dose if hypotension or marked vasodilatory adverse effects appear.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
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