Drug interactions
Nintedanib + Quinine
Severity: Moderate
Nintedanib and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine inhibits P-glycoprotein, which may increase nintedanib exposure. Higher levels could worsen gastrointestinal effects such as diarrhea and nausea and raise the risk of liver enzyme elevations.
What this interaction means in plain words
Nintedanib and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nintedanib belongs to Oncology; Quinine belongs to Anti Parasitic.
Why it happens
Inhibition of P-glycoprotein efflux of nintedanib by quinine, increasing its absorption and reducing clearance.
What to do
Monitor for nintedanib adverse effects and liver enzymes during co-therapy. Interrupt or reduce the nintedanib dose if intolerance develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
Frequently asked questions
Can I take Nintedanib with Quinine?
MediHelp rates the interaction as moderate. Nintedanib and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinine inhibits P-glycoprotein, which may increase nintedanib exposure. Higher levels could worsen gastrointestinal effects such as diarrhea and nausea and raise the risk of liver enzyme elevations.
How serious is the interaction between Nintedanib and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for nintedanib adverse effects and liver enzymes during co-therapy. Interrupt or reduce the nintedanib dose if intolerance develops.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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