Drug interactions
Nintedanib + Sunitinib
Severity: Moderate
Nintedanib and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sunitinib may inhibit P-glycoprotein and so raise nintedanib exposure. Additive toxicity such as diarrhea, hepatotoxicity and bleeding may also occur.
What this interaction means in plain words
Nintedanib and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nintedanib belongs to Oncology; Sunitinib belongs to Oncology.
Why it happens
P-gp inhibition reduces nintedanib efflux; additive pharmacodynamic toxicity is also possible.
What to do
Monitor liver tests and gastrointestinal tolerance. Interrupt or reduce the nintedanib dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
Frequently asked questions
Can I take Nintedanib with Sunitinib?
MediHelp rates the interaction as moderate. Nintedanib and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sunitinib may inhibit P-glycoprotein and so raise nintedanib exposure. Additive toxicity such as diarrhea, hepatotoxicity and bleeding may also occur.
How serious is the interaction between Nintedanib and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver tests and gastrointestinal tolerance. Interrupt or reduce the nintedanib dose if adverse effects occur.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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