Drug interactions
Nirmatrelvir / ritonavir + Tenofovir alafenamide
Severity: Minor
Nirmatrelvir / ritonavir and Tenofovir alafenamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir inhibits P-glycoprotein, increasing intestinal absorption of tenofovir alafenamide and raising tenofovir exposure. Boosted regimens are labeled for use with a reduced tenofovir alafenamide dose in some products, and short courses of nirmatrelvir/ritonavir are generally considered acceptable.
What this interaction means in plain words
Nirmatrelvir / ritonavir and Tenofovir alafenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Ritonavir inhibits intestinal P-gp efflux of tenofovir alafenamide, increasing its absorption.
What to do
No dose change is typically needed for the short 5-day course. Monitor renal function if used in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tenofovir alafenamide
- Apalutamide + Tenofovir alafenamide Major
- Berotralstat + Tenofovir alafenamide Moderate
- Danicopan + Tenofovir alafenamide Moderate
- Ifosfamide + Tenofovir alafenamide Moderate
- Orlistat + Tenofovir alafenamide Moderate
- Sotorasib + Tenofovir alafenamide Moderate
Frequently asked questions
Can I take Nirmatrelvir / ritonavir with Tenofovir alafenamide?
MediHelp rates the interaction as minor. Nirmatrelvir / ritonavir and Tenofovir alafenamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ritonavir inhibits P-glycoprotein, increasing intestinal absorption of tenofovir alafenamide and raising tenofovir exposure. Boosted regimens are labeled for use with a reduced tenofovir alafenamide dose in some products, and short courses of nirmatrelvir/ritonavir are generally considered acceptable.
How serious is the interaction between Nirmatrelvir / ritonavir and Tenofovir alafenamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is typically needed for the short 5-day course. Monitor renal function if used in patients with renal impairment.
What other medicines interact with Tenofovir alafenamide?
MediHelp also lists interactions of Tenofovir alafenamide with, for example, Apalutamide, Berotralstat, Danicopan. The full list is on the Tenofovir alafenamide page.
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