Drug interactions
Nisoldipine + Succinylcholine
Severity: Minor
Nisoldipine and Succinylcholine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers can potentiate neuromuscular blockade and may prolong the effect of succinylcholine. Clinical significance with nisoldipine is likely small but recovery may be delayed in some patients.
What this interaction means in plain words
Nisoldipine and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nisoldipine belongs to Cardiovascular; Succinylcholine belongs to Musculoskeletal.
Why it happens
Calcium channel blockade may reduce prejunctional acetylcholine release, modestly enhancing neuromuscular blockade.
What to do
Monitor neuromuscular recovery with a nerve stimulator and titrate muscle relaxant dosing to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Succinylcholine
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Nisoldipine with Succinylcholine?
MediHelp rates the interaction as minor. Nisoldipine and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers can potentiate neuromuscular blockade and may prolong the effect of succinylcholine. Clinical significance with nisoldipine is likely small but recovery may be delayed in some patients.
How serious is the interaction between Nisoldipine and Succinylcholine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular recovery with a nerve stimulator and titrate muscle relaxant dosing to response.
What other medicines interact with Succinylcholine?
MediHelp also lists interactions of Succinylcholine with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Succinylcholine page.
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