Drug interactions
Nisoldipine + Tizanidine
Severity: Moderate
Nisoldipine and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tizanidine is a centrally acting alpha-2 agonist that lowers blood pressure, and nisoldipine is a dihydropyridine calcium channel blocker with strong vasodilating effects. Used together they can produce additive hypotension, with dizziness or fainting, particularly at treatment start or after dose increases.
What this interaction means in plain words
Nisoldipine and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nisoldipine belongs to Cardiovascular; Tizanidine belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic blood pressure lowering through central sympatholytic action and peripheral vasodilation.
What to do
Monitor blood pressure and orthostatic symptoms when starting or titrating either drug. Begin tizanidine at a low dose and reduce the dose of either agent if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Nisoldipine with Tizanidine?
MediHelp rates the interaction as moderate. Nisoldipine and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tizanidine is a centrally acting alpha-2 agonist that lowers blood pressure, and nisoldipine is a dihydropyridine calcium channel blocker with strong vasodilating effects. Used together they can produce additive hypotension, with dizziness or fainting, particularly at treatment start or after dose increases.
How serious is the interaction between Nisoldipine and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or titrating either drug. Begin tizanidine at a low dose and reduce the dose of either agent if symptomatic hypotension occurs.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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