Drug interactions
Nitazoxanide + Sulindac
Severity: Minor
Nitazoxanide and Sulindac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tizoxanide, the active metabolite of nitazoxanide, is highly protein bound, as is sulindac. Displacement is theoretically possible, but clinically significant interactions have not been established.
What this interaction means in plain words
Nitazoxanide and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nitazoxanide belongs to Anti Bacterial; Sulindac belongs to Musculoskeletal.
Why it happens
Theoretical competition for plasma protein binding sites; not established as clinically relevant.
What to do
No routine adjustment is needed. Monitor for NSAID adverse effects if used with other highly protein-bound drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Nitazoxanide
Frequently asked questions
Can I take Nitazoxanide with Sulindac?
MediHelp rates the interaction as minor. Nitazoxanide and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tizoxanide, the active metabolite of nitazoxanide, is highly protein bound, as is sulindac. Displacement is theoretically possible, but clinically significant interactions have not been established.
How serious is the interaction between Nitazoxanide and Sulindac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for NSAID adverse effects if used with other highly protein-bound drugs.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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