Drug interactions
Nitazoxanide + Tolbutamide
Severity: Minor
Nitazoxanide and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitazoxanide's active metabolite, tizoxanide, is highly protein bound and could theoretically displace highly bound drugs such as tolbutamide. A clinically significant effect has not been established, and short courses make it unlikely.
What this interaction means in plain words
Nitazoxanide and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nitazoxanide belongs to Anti Bacterial; Tolbutamide belongs to Endocrine.
Why it happens
Theoretical plasma protein binding displacement.
What to do
No routine change is needed; monitor blood glucose during the nitazoxanide course if hypoglycemia symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Other interactions of Nitazoxanide
Frequently asked questions
Can I take Nitazoxanide with Tolbutamide?
MediHelp rates the interaction as minor. Nitazoxanide and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nitazoxanide's active metabolite, tizoxanide, is highly protein bound and could theoretically displace highly bound drugs such as tolbutamide. A clinically significant effect has not been established, and short courses make it unlikely.
How serious is the interaction between Nitazoxanide and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor blood glucose during the nitazoxanide course if hypoglycemia symptoms occur.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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