Drug interactions
Nitrofurantoin + Oteseconazole
Severity: Minor
Nitrofurantoin and Oteseconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oteseconazole inhibits BCRP, and nitrofurantoin is a BCRP substrate, so nitrofurantoin levels may be higher. The expected clinical effect is modest.
What this interaction means in plain words
Nitrofurantoin and Oteseconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nitrofurantoin belongs to Anti Bacterial; Oteseconazole belongs to Anti Fungals.
Why it happens
Oteseconazole inhibits BCRP-mediated efflux, potentially increasing nitrofurantoin exposure.
What to do
No routine dose change is required; monitor for nitrofurantoin adverse effects, especially if renal function is reduced or treatment is prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nitrofurantoin
Other interactions of Oteseconazole
- Atorvastatin + Oteseconazole Moderate
- Fluvastatin + Oteseconazole Moderate
- Glyburide-metformin + Oteseconazole Moderate
- Glyburide + Oteseconazole Moderate
- Irinotecan + Oteseconazole Moderate
- Lapatinib + Oteseconazole Moderate
Frequently asked questions
Can I take Nitrofurantoin with Oteseconazole?
MediHelp rates the interaction as minor. Nitrofurantoin and Oteseconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oteseconazole inhibits BCRP, and nitrofurantoin is a BCRP substrate, so nitrofurantoin levels may be higher. The expected clinical effect is modest.
How serious is the interaction between Nitrofurantoin and Oteseconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required; monitor for nitrofurantoin adverse effects, especially if renal function is reduced or treatment is prolonged.
What other medicines interact with Nitrofurantoin?
MediHelp also lists interactions of Nitrofurantoin with, for example, Pexidartinib, Pretomanid, Aluminum hydroxide. The full list is on the Nitrofurantoin page.
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