Drug interactions
Nitroglycerin rectal + Silodosin
Severity: Moderate
Nitroglycerin rectal and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroglycerin is a potent vasodilator and combined with silodosin may produce additive hypotension. Dizziness, falls and syncope are the main concerns.
What this interaction means in plain words
Nitroglycerin rectal and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation from nitrate-mediated venodilation and alpha-1 blockade.
What to do
Monitor blood pressure and have the patient sit or lie down when using nitroglycerin. Reduce doses if orthostatic symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Nitroglycerin rectal with Silodosin?
MediHelp rates the interaction as moderate. Nitroglycerin rectal and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroglycerin is a potent vasodilator and combined with silodosin may produce additive hypotension. Dizziness, falls and syncope are the main concerns.
How serious is the interaction between Nitroglycerin rectal and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and have the patient sit or lie down when using nitroglycerin. Reduce doses if orthostatic symptoms occur.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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