Drug interactions
Norethisterone + Tecovirimat
Severity: Minor
Norethisterone and Tecovirimat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat is a weak CYP3A4 inducer and may modestly lower norethisterone exposure. The effect on contraceptive efficacy is probably small but possible.
What this interaction means in plain words
Norethisterone and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Norethisterone belongs to Endocrine; Tecovirimat belongs to Miscellaneous.
Why it happens
Weak CYP3A4 induction by tecovirimat increases norethisterone clearance.
What to do
Consider a backup non-hormonal contraceptive method during the short tecovirimat course and monitor for breakthrough bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Norethisterone
- Acitretin + Norethisterone Contraindicated
- Amobarbital + Norethisterone Major
- Apalutamide + Norethisterone Major
- Belzutifan + Norethisterone Major
- Bosentan + Norethisterone Major
- Brigatinib + Norethisterone Major
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Norethisterone with Tecovirimat?
MediHelp rates the interaction as minor. Norethisterone and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tecovirimat is a weak CYP3A4 inducer and may modestly lower norethisterone exposure. The effect on contraceptive efficacy is probably small but possible.
How serious is the interaction between Norethisterone and Tecovirimat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a backup non-hormonal contraceptive method during the short tecovirimat course and monitor for breakthrough bleeding.
What other medicines interact with Norethisterone?
MediHelp also lists interactions of Norethisterone with, for example, Acitretin, Amobarbital, Apalutamide. The full list is on the Norethisterone page.
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