Drug interactions
Norethisterone + Voriconazole
Severity: Moderate
Norethisterone and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4 and can raise norethisterone exposure, with studies showing increased levels when given with oral contraceptives. This may increase hormonal adverse effects such as nausea, breast tenderness and thromboembolic risk when combined with estrogen.
What this interaction means in plain words
Norethisterone and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Norethisterone belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4, reducing the metabolism of norethisterone.
What to do
Monitor for hormonal adverse effects during voriconazole therapy. Consider dose reduction or an alternative contraceptive if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Norethisterone
- Acitretin + Norethisterone Contraindicated
- Amobarbital + Norethisterone Major
- Apalutamide + Norethisterone Major
- Belzutifan + Norethisterone Major
- Bosentan + Norethisterone Major
- Brigatinib + Norethisterone Major
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Norethisterone with Voriconazole?
MediHelp rates the interaction as moderate. Norethisterone and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP3A4 and can raise norethisterone exposure, with studies showing increased levels when given with oral contraceptives. This may increase hormonal adverse effects such as nausea, breast tenderness and thromboembolic risk when combined with estrogen.
How serious is the interaction between Norethisterone and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hormonal adverse effects during voriconazole therapy. Consider dose reduction or an alternative contraceptive if adverse effects occur.
What other medicines interact with Norethisterone?
MediHelp also lists interactions of Norethisterone with, for example, Acitretin, Amobarbital, Apalutamide. The full list is on the Norethisterone page.
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