Drug interactions
Nortriptyline + Prochlorperazine
Severity: Moderate
Nortriptyline and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval and cause sedation, and both have anticholinergic properties. Together they raise the risk of arrhythmia, excessive drowsiness and anticholinergic effects such as constipation, urinary retention and confusion.
What this interaction means in plain words
Nortriptyline and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nortriptyline belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation through cardiac potassium channel blockade, plus additive sedative and anticholinergic effects; prochlorperazine may also inhibit CYP2D6 modestly.
What to do
Obtain a baseline ECG in patients with cardiac risk factors and correct potassium and magnesium. Monitor for sedation and anticholinergic effects and reduce doses if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Nortriptyline with Prochlorperazine?
MediHelp rates the interaction as moderate. Nortriptyline and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval and cause sedation, and both have anticholinergic properties. Together they raise the risk of arrhythmia, excessive drowsiness and anticholinergic effects such as constipation, urinary retention and confusion.
How serious is the interaction between Nortriptyline and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with cardiac risk factors and correct potassium and magnesium. Monitor for sedation and anticholinergic effects and reduce doses if they occur.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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