Drug interactions
Nortriptyline + Progesterone
Severity: Minor
Nortriptyline and Progesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sex steroid hormones have been reported to alter the response to tricyclic antidepressants, with possible changes in efficacy and in plasma levels. Data for progesterone are limited and any effect is likely modest.
What this interaction means in plain words
Nortriptyline and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nortriptyline belongs to Central Nervous System; Progesterone belongs to Endocrine.
Why it happens
The mechanism is not well established; hormonal effects on hepatic metabolism of the tricyclic have been proposed.
What to do
No routine adjustment is needed; if response or adverse effects change after hormone initiation, consider checking nortriptyline serum levels and adjusting the dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Progesterone
Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Nortriptyline with Progesterone?
MediHelp rates the interaction as minor. Nortriptyline and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sex steroid hormones have been reported to alter the response to tricyclic antidepressants, with possible changes in efficacy and in plasma levels. Data for progesterone are limited and any effect is likely modest.
How serious is the interaction between Nortriptyline and Progesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; if response or adverse effects change after hormone initiation, consider checking nortriptyline serum levels and adjusting the dose.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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