Drug interactions
Nortriptyline + Propofol
Severity: Moderate
Nortriptyline and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nortriptyline may add to the sedative and hypotensive effects of propofol. Tricyclics can also increase arrhythmia risk during anesthesia.
What this interaction means in plain words
Nortriptyline and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nortriptyline belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depression and cardiovascular effects.
What to do
Titrate propofol carefully to effect and monitor blood pressure and ECG. Inform the anesthesia team of tricyclic use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Propofol
Frequently asked questions
Can I take Nortriptyline with Propofol?
MediHelp rates the interaction as moderate. Nortriptyline and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nortriptyline may add to the sedative and hypotensive effects of propofol. Tricyclics can also increase arrhythmia risk during anesthesia.
How serious is the interaction between Nortriptyline and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol carefully to effect and monitor blood pressure and ECG. Inform the anesthesia team of tricyclic use.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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