Drug interactions
Ocrelizumab + Prednisone
Severity: Moderate
Ocrelizumab and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ocrelizumab depletes B cells and increases infection risk, and concomitant corticosteroids, especially at high doses or for prolonged periods, add to the immunosuppression. Short methylprednisolone premedication is standard, but sustained steroid use increases infection concern.
What this interaction means in plain words
Ocrelizumab and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ocrelizumab belongs to Central Nervous System; Prednisone belongs to Endocrine.
Why it happens
Additive immunosuppression from B-cell depletion and broad glucocorticoid suppression of immune function.
What to do
Limit corticosteroid dose and duration where possible and monitor for infections, screening for hepatitis B before ocrelizumab. Avoid live vaccines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Frequently asked questions
Can I take Ocrelizumab with Prednisone?
MediHelp rates the interaction as moderate. Ocrelizumab and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ocrelizumab depletes B cells and increases infection risk, and concomitant corticosteroids, especially at high doses or for prolonged periods, add to the immunosuppression. Short methylprednisolone premedication is standard, but sustained steroid use increases infection concern.
How serious is the interaction between Ocrelizumab and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit corticosteroid dose and duration where possible and monitor for infections, screening for hepatitis B before ocrelizumab. Avoid live vaccines.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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