Drug interactions
Ofloxacin + Posaconazole
Severity: Major
Ofloxacin and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole prolongs the QT interval and ofloxacin may add to it. Combined use increases the risk of torsades de pointes, especially with hypokalemia, cardiac disease or other QT-prolonging drugs.
What this interaction means in plain words
Ofloxacin and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ofloxacin belongs to Anti Bacterial; Posaconazole belongs to Anti Fungals.
Why it happens
Additive delayed cardiac repolarization through potassium channel effects.
What to do
Avoid the combination when possible and choose a non-QT-prolonging antibiotic. If used, correct potassium and magnesium and monitor the ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Ofloxacin with Posaconazole?
MediHelp rates the interaction as major. Ofloxacin and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole prolongs the QT interval and ofloxacin may add to it. Combined use increases the risk of torsades de pointes, especially with hypokalemia, cardiac disease or other QT-prolonging drugs.
How serious is the interaction between Ofloxacin and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible and choose a non-QT-prolonging antibiotic. If used, correct potassium and magnesium and monitor the ECG.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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