Drug interactions
Oliceridine + Trazodone
Severity: Major
Oliceridine and Trazodone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone may modestly raise oliceridine exposure through CYP2D6 inhibition, increasing opioid effects such as sedation and respiratory depression. Both agents have serotonergic activity, and serotonin syndrome is possible, and CNS depression is additive.
What this interaction means in plain words
Oliceridine and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oliceridine belongs to Musculoskeletal; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression, possible CYP2D6 inhibition, and additive serotonergic effects.
What to do
Titrate oliceridine cautiously with close monitoring of sedation and respiratory rate. Watch for serotonin syndrome features.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Trazodone?
MediHelp rates the interaction as major. Oliceridine and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trazodone may modestly raise oliceridine exposure through CYP2D6 inhibition, increasing opioid effects such as sedation and respiratory depression. Both agents have serotonergic activity, and serotonin syndrome is possible, and CNS depression is additive.
How serious is the interaction between Oliceridine and Trazodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate oliceridine cautiously with close monitoring of sedation and respiratory rate. Watch for serotonin syndrome features.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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