Drug interactions
Oliceridine + Trimipramine
Severity: Major
Oliceridine and Trimipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids and tricyclic antidepressants together increase sedation and respiratory depression. Trimipramine's anticholinergic action may add to opioid-related constipation and urinary retention, and some serotonergic interaction is possible.
What this interaction means in plain words
Oliceridine and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oliceridine belongs to Musculoskeletal; Trimipramine belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression, additive anticholinergic effects on gut and bladder, and possible serotonergic contribution.
What to do
Use the lowest effective oliceridine dose with monitoring of sedation and respiratory rate. Watch for urinary retention, severe constipation, and serotonin toxicity features.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Trimipramine?
MediHelp rates the interaction as major. Oliceridine and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids and tricyclic antidepressants together increase sedation and respiratory depression. Trimipramine's anticholinergic action may add to opioid-related constipation and urinary retention, and some serotonergic interaction is possible.
How serious is the interaction between Oliceridine and Trimipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective oliceridine dose with monitoring of sedation and respiratory rate. Watch for urinary retention, severe constipation, and serotonin toxicity features.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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