Drug interactions
Omaveloxolone + Paclitaxel
Severity: Minor
Omaveloxolone and Paclitaxel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone may induce CYP2C8, the main enzyme metabolizing paclitaxel, and could lower paclitaxel exposure. The clinical effect on antitumor efficacy is uncertain.
What this interaction means in plain words
Omaveloxolone and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Omaveloxolone belongs to Central Nervous System; Paclitaxel belongs to Oncology.
Why it happens
Possible CYP2C8 induction by omaveloxolone increases paclitaxel metabolism.
What to do
Monitor for reduced paclitaxel effectiveness and review prescribing information for dose guidance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paclitaxel
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Omaveloxolone with Paclitaxel?
MediHelp rates the interaction as minor. Omaveloxolone and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omaveloxolone may induce CYP2C8, the main enzyme metabolizing paclitaxel, and could lower paclitaxel exposure. The clinical effect on antitumor efficacy is uncertain.
How serious is the interaction between Omaveloxolone and Paclitaxel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced paclitaxel effectiveness and review prescribing information for dose guidance.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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