Drug interactions
Omaveloxolone + Quinidine
Severity: Moderate
Omaveloxolone and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone may induce CYP3A4 and reduce exposure to sensitive substrates such as quinidine. Lower quinidine concentrations could reduce efficacy.
What this interaction means in plain words
Omaveloxolone and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Omaveloxolone belongs to Central Nervous System; Quinidine belongs to Anti Parasitic.
Why it happens
Omaveloxolone induces CYP3A4, increasing quinidine clearance.
What to do
Monitor quinidine levels and clinical or ECG response after starting omaveloxolone. Increase the quinidine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Omaveloxolone with Quinidine?
MediHelp rates the interaction as moderate. Omaveloxolone and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omaveloxolone may induce CYP3A4 and reduce exposure to sensitive substrates such as quinidine. Lower quinidine concentrations could reduce efficacy.
How serious is the interaction between Omaveloxolone and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor quinidine levels and clinical or ECG response after starting omaveloxolone. Increase the quinidine dose if needed.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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