Drug interactions
Omaveloxolone + Repaglinide
Severity: Moderate
Omaveloxolone and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone may lower exposure to sensitive CYP3A4 and CYP2C8 substrates such as repaglinide, which is cleared by both enzymes. This could reduce glycemic control.
What this interaction means in plain words
Omaveloxolone and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Omaveloxolone belongs to Central Nervous System; Repaglinide belongs to Endocrine.
Why it happens
Omaveloxolone induces CYP3A4 and CYP2C8, increasing repaglinide metabolism.
What to do
Monitor blood glucose after starting omaveloxolone and increase the repaglinide dose if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Omaveloxolone with Repaglinide?
MediHelp rates the interaction as moderate. Omaveloxolone and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omaveloxolone may lower exposure to sensitive CYP3A4 and CYP2C8 substrates such as repaglinide, which is cleared by both enzymes. This could reduce glycemic control.
How serious is the interaction between Omaveloxolone and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting omaveloxolone and increase the repaglinide dose if control worsens.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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