Drug interactions
Omaveloxolone + Secobarbital
Severity: Major
Omaveloxolone and Secobarbital: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone is metabolized by CYP3A4, and barbiturates may lower its exposure through induction. This may reduce its therapeutic benefit in Friedreich ataxia.
What this interaction means in plain words
Omaveloxolone and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Omaveloxolone belongs to Central Nervous System; Secobarbital belongs to Central Nervous System.
Why it happens
CYP3A4 induction by secobarbital increases omaveloxolone clearance.
What to do
Avoid concurrent use and select a non-inducing alternative. If the barbiturate is required, monitor clinical response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Omaveloxolone with Secobarbital?
MediHelp rates the interaction as major. Omaveloxolone and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Omaveloxolone is metabolized by CYP3A4, and barbiturates may lower its exposure through induction. This may reduce its therapeutic benefit in Friedreich ataxia.
How serious is the interaction between Omaveloxolone and Secobarbital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and select a non-inducing alternative. If the barbiturate is required, monitor clinical response.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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