Drug interactions
Omaveloxolone + Sertraline
Severity: Minor
Omaveloxolone and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone is metabolised mainly by CYP3A4, and inhibitors raise exposure and adverse effects such as liver enzyme elevation. Sertraline is a weak CYP3A4 inhibitor so the effect is likely small.
What this interaction means in plain words
Omaveloxolone and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Omaveloxolone belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by sertraline reducing omaveloxolone clearance.
What to do
No empirical dose change is needed; monitor liver enzymes and adverse effects. Reduce omaveloxolone per labeling if a stronger inhibitor is added.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Omaveloxolone with Sertraline?
MediHelp rates the interaction as minor. Omaveloxolone and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omaveloxolone is metabolised mainly by CYP3A4, and inhibitors raise exposure and adverse effects such as liver enzyme elevation. Sertraline is a weak CYP3A4 inhibitor so the effect is likely small.
How serious is the interaction between Omaveloxolone and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor liver enzymes and adverse effects. Reduce omaveloxolone per labeling if a stronger inhibitor is added.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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