Drug interactions
Omaveloxolone + Thioridazine
Severity: Minor
Omaveloxolone and Thioridazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone may induce CYP3A4 and could lower exposure to CYP3A4 substrates. However, thioridazine is metabolized mainly by CYP2D6, with CYP3A4 playing a minor role, so a meaningful effect on thioridazine is unlikely.
What this interaction means in plain words
Omaveloxolone and Thioridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Omaveloxolone belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by omaveloxolone with a minor contribution of CYP3A4 to thioridazine metabolism.
What to do
No dose adjustment is expected to be needed. Monitor clinical response to thioridazine if therapy changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Omaveloxolone with Thioridazine?
MediHelp rates the interaction as minor. Omaveloxolone and Thioridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omaveloxolone may induce CYP3A4 and could lower exposure to CYP3A4 substrates. However, thioridazine is metabolized mainly by CYP2D6, with CYP3A4 playing a minor role, so a meaningful effect on thioridazine is unlikely.
How serious is the interaction between Omaveloxolone and Thioridazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is expected to be needed. Monitor clinical response to thioridazine if therapy changes.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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