Drug interactions
Omaveloxolone + Valproic acid
Severity: Minor
Omaveloxolone and Valproic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone may weakly induce CYP3A4, but valproate is cleared mainly by glucuronidation and mitochondrial beta-oxidation with only minor CYP involvement. A clinically meaningful drop in valproate levels is unlikely.
What this interaction means in plain words
Omaveloxolone and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Omaveloxolone belongs to Central Nervous System; Valproic acid belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by omaveloxolone acting on a minor valproate pathway.
What to do
No routine adjustment is needed. Check valproate levels if seizure control or mood stability changes after starting omaveloxolone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Omaveloxolone and Valproic acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Omaveloxolone with Valproic acid?
MediHelp rates the interaction as minor. Omaveloxolone and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omaveloxolone may weakly induce CYP3A4, but valproate is cleared mainly by glucuronidation and mitochondrial beta-oxidation with only minor CYP involvement. A clinically meaningful drop in valproate levels is unlikely.
How serious is the interaction between Omaveloxolone and Valproic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Check valproate levels if seizure control or mood stability changes after starting omaveloxolone.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
