Drug interactions
Omaveloxolone + Verapamil
Severity: Moderate
Omaveloxolone and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may raise omaveloxolone exposure, increasing risks of transaminase elevation and other adverse effects.
What this interaction means in plain words
Omaveloxolone and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Omaveloxolone belongs to Central Nervous System; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4-mediated omaveloxolone metabolism.
What to do
Avoid if possible. If unavoidable, reduce omaveloxolone to 100 mg daily and monitor liver tests and adverse effects, reducing further to 50 mg if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Omaveloxolone with Verapamil?
MediHelp rates the interaction as moderate. Omaveloxolone and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may raise omaveloxolone exposure, increasing risks of transaminase elevation and other adverse effects.
How serious is the interaction between Omaveloxolone and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, reduce omaveloxolone to 100 mg daily and monitor liver tests and adverse effects, reducing further to 50 mg if needed.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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