Drug interactions
Omaveloxolone + Warfarin
Severity: Minor
Omaveloxolone and Warfarin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone is a weak to moderate CYP3A4 inducer and may modestly lower exposure to the R-enantiomer of warfarin. The effect on INR is likely small.
What this interaction means in plain words
Omaveloxolone and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Omaveloxolone belongs to Central Nervous System; Warfarin belongs to Cardiovascular.
Why it happens
Induction of CYP3A4 increases metabolism of R-warfarin.
What to do
Check INR after starting or stopping omaveloxolone and adjust the warfarin dose if the INR changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Omaveloxolone with Warfarin?
MediHelp rates the interaction as minor. Omaveloxolone and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omaveloxolone is a weak to moderate CYP3A4 inducer and may modestly lower exposure to the R-enantiomer of warfarin. The effect on INR is likely small.
How serious is the interaction between Omaveloxolone and Warfarin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR after starting or stopping omaveloxolone and adjust the warfarin dose if the INR changes.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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