Drug interactions
Omeprazole + Ospemifene
Severity: Minor
Omeprazole and Ospemifene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omeprazole inhibits CYP2C19, which contributes to ospemifene metabolism, so ospemifene exposure may increase modestly. The clinical effect is generally small.
What this interaction means in plain words
Omeprazole and Ospemifene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Omeprazole belongs to Gastrointestinal Tract; Ospemifene belongs to Endocrine.
Why it happens
Omeprazole inhibits CYP2C19-mediated metabolism of ospemifene.
What to do
No routine dose change is needed; monitor for ospemifene adverse effects such as hot flushes or vaginal discharge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Estradiol + Ospemifene Contraindicated
- Clomiphene + Ospemifene Major
- Fluconazole + Ospemifene Major
- Ketoconazole + Ospemifene Major
- Ospemifene + Raloxifene Major
Frequently asked questions
Can I take Omeprazole with Ospemifene?
MediHelp rates the interaction as minor. Omeprazole and Ospemifene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omeprazole inhibits CYP2C19, which contributes to ospemifene metabolism, so ospemifene exposure may increase modestly. The clinical effect is generally small.
How serious is the interaction between Omeprazole and Ospemifene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for ospemifene adverse effects such as hot flushes or vaginal discharge.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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