Drug interactions
Omeprazole + Tazemetostat
Severity: Minor
Omeprazole and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak CYP3A4 inducer and may lower exposure of CYP3A substrates such as omeprazole. Omeprazole is a weak CYP3A4 inhibitor and might modestly increase tazemetostat levels. Effects are likely small.
What this interaction means in plain words
Omeprazole and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Omeprazole belongs to Gastrointestinal Tract; Tazemetostat belongs to Miscellaneous.
Why it happens
Tazemetostat induces CYP3A4 while omeprazole may weakly inhibit it, giving bidirectional effects on metabolism.
What to do
Usually no adjustment is needed; monitor for reduced acid control or tazemetostat adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Omeprazole and Tazemetostat, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Omeprazole with Tazemetostat?
MediHelp rates the interaction as minor. Omeprazole and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak CYP3A4 inducer and may lower exposure of CYP3A substrates such as omeprazole. Omeprazole is a weak CYP3A4 inhibitor and might modestly increase tazemetostat levels. Effects are likely small.
How serious is the interaction between Omeprazole and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no adjustment is needed; monitor for reduced acid control or tazemetostat adverse effects.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
